PhotoSonus M

High Energy, Mobile, Tunable Wavelength Laser Source for Photoacoustic Imaging
  • Pump laser, OPO and PSU in a single mobile unit
  • High 250 mJ output energy
  • Wide tuning range from 330 to 2300 nm
  • Fast wavelength tuning available
  • photoacoustics photosonus
  • Pump laser, OPO and PSU in a single mobile unit
  • High 250 mJ output energy
  • Wide tuning range from 330 to 2300 nm
  • Fast wavelength tuning available
  • photoacoustics photosonus

Features & Options


  • High up to 250 mJ output energy
  • Wide tuning range from 330 to 2300 nm
  • Ultra-wide OPO signal tuning range from 660 to 1320 nm
  • 10 Hz or 20 Hz pulse repetition rate
  • Integrated pump laser, OPO and PSU in single mobile unit
  • Low maintenance cost
  • Fiber bundle connectors with safety interlock
  • Fast wavelength switching within entire signal or idler range between two consecutive pulses
  • Integrated energy meter (optional)
  • Motorized attenuator (optional)
  • Access to pump laser wavelengths 1064/532 nm (optional)


Following the demand for high output energies in the photoacoustic market for imaging larger volumes of tissue, PhotoSonus M, an updated high energy tunable laser source for photo-acoustic imaging, was introduced. Time-tested Ekspla nanosecond pump laser, parametric oscillator, power supply and cooling unit are integrated in a single robust housing to provide mobility, ease of use and low maintenance cost. The highly flexible PhotoSonus M platform makes it easily integrated and used in a photoacoustic imaging system. It is fully motorized and computer controlled, with user trigger outputs and inputs and special options such as motorized switching between OPO Signal and Idler, motorized attenuator, internal energy meter and electromechanical output shutter.

Recently, a fast wavelength switching option was introduced that enables each laser pulse to have a different wavelength within the entire signal or idler range and at any sequence. This new feature, combining high pulse energy (up to 180 mJ) and wide wavelength tuning range (330 – 2300 nm) makes PhotoSonus M the irreplaceable imaging source for any photo acoustic system.

For even higher sample imaging depth and resolution a PhotoSonus M+, with up to 250 mJ maximum pulse energy, was introduced.

For convenience, the outputs of PhotoSonus M and PhotoSonus M+ lasers can be coupled with almost any type of fiber bundle.


MODEL 1)PhotoSonus M-10PhotoSonus M-20PhotoSonus M+
Wavelength range
    Signal660 – 1320 nm660 – 1064 nm 2)
    SH extension range (optional)330 – 659 nm330 – 530 nm (330 – 659 nm 3) )
    Idler (optional)1065 – 2300 nm
OPO output MAX pulse energy 4)>180 mJ>160 mJ>250 mJ
Pulse repetition rate10 Hz20 Hz10 Hz
Scanning step:
    Signal0.1 nm
    Idler1 nm
Pulse duration 5)3 – 5 ns
Signal linewidth 6)<10 cm-1
Typical signal beam diameter (1/e²) 7)7 ± 2 mm9 ± 2 mm
Unit size (W × L × H)434 × 672 × 887 mm
Room temperature18 – 27 °C
Relative humidity20 – 80 % (non-condensing)
Power requirements 8)208 or 240 VAC, single phase 50/60 Hz
Power consumption<1.0 kVA<1.5 kVA<1.5 kVA
  1. Due to continuous improvement, all specifications are subject to change without notice. The parameters marked typical are not specifications. They are indications of typical performance and will vary with each unit we manufacture. Unless stated otherwise all specifications are measured at 700 nm.
  2. Optional signal extended range: 660 – 1320 nm.
  3. When extended signal range is selected.
  4. Measured at the free space output. See tuning curves for typical energy levels at different wavelengths.
  5. FWHM measured with photodiode featuring 1 ns rise time and 300 MHz bandwidth oscilloscope.
  6. At 700 nm or higher wavelengths.
  7. Measured at the free space output at 700 nm. Can be adjusted as per request.
  8. Mains voltage should be specified when ordering.

Performance & Drawings

Applications Examples


Found total :
11 articles, 11 selected
Application selected :
All Applications
Biomedical – applications focusing on the biology of human health and disease
Photoacoustic Imaging – biomedical imaging modality based on the photoacoustic effect
All Applications

Wide-field three-dimensional photoacoustic/ultrasound scanner using a two-dimensional matrix transducer array

Related applications:  Biomedical Photoacoustic Imaging

Authors:  W. Kim, W. Choi, J. Ahn, C. Lee, and C. Kim

Two-dimensional matrix transducer arrays are the most appropriate imaging probes for acquiring dual-modal 3D photoacoustic (PA)/ultrasound (US) images. However, they have small footprints which limit the field-of-view (FOV) to less than 10 mm × 10 mm and degrade the spatial resolution. In this study, we demonstrate a dual-modal PA and US imaging system (using a 2D matrix transducer array and a motorized 2D scanning system) to enlarge the FOV of volumetric images. Multiple PA volumes were merged to form a wide-field image of approximately 45 mm × 45 mm. In vivo imaging was demonstrated using rat sentinel lymph nodes (SLNs) and bladders stained with methylene blue. We believe that this volumetric PA/US imaging technique with a 2D matrix transducer array can be a useful tool for narrow-field real-time monitoring and wide-field imaging of various preclinical and clinical studies.

Published: 2023.   Source: Opt. Lett. 48, 343-346 (2023)

An Investigation of Signal Preprocessing for Photoacoustic Tomography

Related applications:  Biomedical Photoacoustic Imaging

Authors:  I. Huen, R. Zhang, R. Bi, X. Li, M. Moothanchery and M. Olivo

Photoacoustic tomography (PAT) is increasingly being used for high-resolution biological imaging at depth. Signal-to-noise ratios and resolution are the main factors that determine image quality. Various reconstruction algorithms have been proposed and applied to reduce noise and enhance resolution, but the efficacy of signal preprocessing methods which also affect image quality, are seldom discussed. We, therefore, compared common preprocessing techniques, namely bandpass filters, wavelet denoising, empirical mode decomposition, and singular value decomposition. Each was compared with and without accounting for sensor directivity. The denoising performance was evaluated with the contrast-to-noise ratio (CNR), and the resolution was calculated as the full width at half maximum (FWHM) in both the lateral and axial directions. In the phantom experiment, counting in directivity was found to significantly reduce noise, outperforming other methods. Irrespective of directivity, the best performing methods for denoising were bandpass, unfiltered, SVD, wavelet, and EMD, in that order. Only bandpass filtering consistently yielded improvements. Significant improvements in the lateral resolution were observed using directivity in two out of three acquisitions. This study investigated the advantages and disadvantages of different preprocessing methods and may help to determine better practices in PAT reconstruction.

Published: 2023.   Source: Sensors 2023, 23, 510

Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging

Related applications:  Biomedical Photoacoustic Imaging

Authors:  S. Singh, G. Giammanco, C.. Hu, J. Bush, L.S. Cordova, D.J. Lawrence, J.L. Moran, P.V. Chitnis, R. Veneziano

Near-infrared photoacoustic imaging (NIR-PAI) combines the advantages of optical and ultrasound imaging to provide anatomical and functional information of tissues with high resolution. Although NIR-PAI is promising, its widespread use is hindered by the limited availability of NIR contrast agents. J-aggregates (JA) made of indocyanine green dye (ICG) represents an attractive class of biocompatible contrast agents for PAI. Here, we present a facile synthesis method that combines ICG and ICG-azide dyes for producing contrast agents with tunable size down to 230 nm and direct functionalization with targeting moieties. The ICG-JA platform has a detectable PA signal in vitro that is two times stronger than whole blood and high photostability. The targeting ability of ICG-JA was measured in vitro using HeLa cells. The ICG-JA platform was then injected into mice and in vivo NIR-PAI showed enhanced visualization of liver and spleen for 90 min post-injection with a contrast-to-noise ratio of 2.42.

Published: 2022.   Source: Photoacoustics, Volume 29, 2023, 100437, ISSN 2213-5979

Deep Learning Enhances Multiparametric Dynamic Volumetric Photoacoustic Computed Tomography In Vivo (DL-PACT)

Related applications:  Biomedical Photoacoustic Imaging

Authors:  S. Choi, J. Yang, S.Y. Lee, J. Kim, J. Lee, W.J. Kim, S. Lee and C. Kim

Photoacoustic computed tomography (PACT) has become a premier preclinical and clinical imaging modality. Although PACT's image quality can be dramatically improved with a large number of ultrasound (US) transducer elements and associated multiplexed data acquisition systems, the associated high system cost and/or slow temporal resolution are significant problems. Here, a deep learning-based approach is demonstrated that qualitatively and quantitively diminishes the limited-view artifacts that reduce image quality and improves the slow temporal resolution. This deep learning-enhanced multiparametric dynamic volumetric PACT approach, called DL-PACT, requires only a clustered subset of many US transducer elements on the conventional multiparametric PACT. Using DL-PACT, high-quality static structural and dynamic contrast-enhanced whole-body images as well as dynamic functional brain images of live animals and humans are successfully acquired, all in a relatively fast and cost-effective manner. It is believed that the strategy can significantly advance the use of PACT technology for preclinical and clinical applications such as neurology, cardiology, pharmacology, endocrinology, and oncology.

Published: 2022.   Source: Adv. Sci. 2022, 10, 2202089

Hydrophones based on interferometric fiber-optic sensors with applications in photoacoustics

Related applications:  Biomedical Photoacoustic Imaging

Authors:  A. D. Salas-Caridad, B. Eng.

Biomedical imaging used for medical diagnosis constantly requires improvement in the characteristics for imaging devices. The sensing devices are one of the most important pieces to improve in order to get images with better quality. In this thesis, it is proposed the use of interferometric fiber-optic sensors (which offer the advantages inherent to optical fibers) as devices to detect pressure/acoustic signals generated by the photoacoustic effect. It is explored the capability of using fiber-optic interferometric hydrophones in order to determine the thickness of a material derived from the acoustic signal generated when a sample is illuminated. In addition, the analysis of photoacoustic signals generated by the excitation of nanoparticles of an anisotropic material as absorption centers. Finally, the cross-section of a metallic sample was photoacoustically imaged by acquiring the pressure signals generated.

Published: 2017.   Source: Master of Optomechatronics | Leon, Guanajuato, Mexico

Hybrid Photoacoustic/Ultrasound tomograph for real time finger imaging

Related applications:  Biomedical Photoacoustic Imaging

Authors:  M. Oeri, W. Bost, N. Sénégond, S. Tretbar, M. Fournelle

We report a target-enclosing, hybrid tomograph with a total of 768 elements based on capacitive micromachined ultrasound transducer technology and providing fast, high-resolution 2-D/3-D photoacoustic and ultrasound tomography tailored to finger imaging.A freely programmable ultrasound beamforming platform sampling data at 80 MHz was developed to realize plane wave transmission under multiple angles. A multiplexing unit enables the connection and control of a large number of elements. Fast image reconstruction is provided by GPU processing. The tomograph is composed of four independent and fully automated movable arc-shaped transducers, allowing imaging of all three finger joints. The system benefits from photoacoustics, yielding high optical contrast and enabling visualization of finger vascularization, and ultrasound provides morphologic information on joints and surrounding tissue. A diode-pumped, Q-switched Nd:YAG laser and an optical parametric oscillator are used to broaden the spectrum of emitted wavelengths to provide multispectral imaging. Custom-made optical fiber bundles enable illumination of the region of interest in the plane of acoustic detection. Precision in positioning of the probe in motion is ensured by use of a motor-driven guide slide. The current position of the probe is encoded by the stage and used to relate ultrasound and photoacoustic signals to the corresponding region of interest of the suspicious finger joint. The system is characterized in phantoms and a healthy human finger in vivo. The results obtained promise to provide new opportunities in finger diagnostics and establish photoacoustic/ultrasoundtomography in medical routine.

Published: 2017.   Source: Ultrasound in Med. & Biol., 2017

Photoacoustic signal detection using interferometric fiber-optic ultrasound transducers

Related applications:  Biomedical Photoacoustic Imaging

Authors:  A. D. Salas-Caridad, G. Martínez-Ponce, R. Martínez-Manuel

The cross-section of a metallic sample was photoacoustically imaged using a pulsed nanosecond laser as the excitation source and a fiber-optic hydrophone system to acquire the pressure signal. The ultrasound sensor was an extrinsic Fabry-Perot fiber-optic interferometer and the band-limited photodetected output signal was recorded in a digital oscilloscope. In order to reconstruct the image, a time set of ultrasound signals acquired in a circular scan around the sample were used to solve the time-reversal equations. It was observed that image contrast can be enhanced considering the deconvolution of the sensor frequency response from each measured pressure signal.

Published: 2017.   Source: Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Detecting Rat’s Kidney Inflammation Using Real Time Photoacoustic Tomography

Related applications:  Biomedical Photoacoustic Imaging

Authors:  M. Y. Lee, D. H. Shin, S. H. Park, W.C. Ham, S.K. Ko, C. G. Song

Photoacoustic Tomography (PAT) is a promising medical imaging modality that combines optical imaging contrast with the spatial resolution of ultrasound imaging. It can also distinguish the changes in biological features. But, real-time PAT system should be confirmed due to photoacoustic effect for tissue. Thus, we have developed a real-time PAT system using a custom-developed data acquisition board and ultrasound linear probe. To evaluate performance of our system, phantom test was performed. As a result of those experiments, the system showed satisfactory performance and its usefulness has been confirmed. We monitored the degradation of inflammation which induced on the rat’s kidney using real-time PAT.

Published: 2017.   Source: World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering Vol:11, No:8, 2017

Image Enchancement Algorithm of Photoacoustic Tomography using Active Countour Filtering

Related applications:  Biomedical Photoacoustic Imaging

Authors:  P. Palaniappan, D. H. Shin, C. G. Song

The photoacoustic images are obtained from a custom developed linear array photoacoustic tomography system. The biological specimens are imitated by conducting phantom tests in order to retrieve a fully functional photoacoustic image. The acquired image undergoes the active region based contour filtering to remove the noise and accurately segment the object area for further processing. The universal vack projection method is used as the image reconstruction algorithm. The active contour filtering is analyzed by evaluating the signal to noise ratio and comparing it with the other filtering methods.

Published: 2016.   Source: World Academy of Science, Engineering and Technology International Journal of Computer and Information Engineering Vol:10, No:4, 2016

A Custom Developed Linear Array Photoacoustic Tomography for Noninvasive Medical Imaging

Related applications:  Biomedical Photoacoustic Imaging

Authors:  P. Palaniappan, D. H. Shin, S. H. Park, M. Y. Lee, B. Y. Kim, S. Y. Lee, S. K. Go, C. G. Song

A real-time photoacoustic tomography which is capable of imaging the changes in biological features of living subject is presented. A custom developed data acquisition board and linear array transducer is used in this photoacoustic system. A phantom test were carried out to evaluate performance of the system. The developed system showed a satisfactory performance and its usefulness were evaluated. The universal back projection algorithm is used for image reconstruction and the sensitivity is analyzed from the obtained photoacoustic images.

Published: 2016.   Source: Event: 2016 IEEE International Conference on Consumer Electronics-Asia (ICCE-Asia)

Enhancement of objects in photoacoustic tomography using selective filtering

Related applications:  Biomedical Photoacoustic Imaging

Authors:  D. Shin, Y. Yang, C. G. Song

Here we developed a real-time photoacoustic tomography (PAT) imaging acquisition device based on the linear array transducer utilized on ultrasonic devices. Also, we produced a phantom including diverse contrast media and acquired PAT imaging as the light source wavelength was changing to see if the contrast media reacted. Indocyanine green showed the highest reaction around the 800-nm band, methylene blue demonstrated the same in the 750-nm band, and gold nanoparticle showed the same in the 700-nm band. However, in the case of superparamagnetic iron oxide, we observed not reaction within the wavelength bands used herein to obtain imaging. Moreover, we applied selective filtering to the acquired PAT imaging to remove noise from around and reinforce the object’s area. Consequentially, we could see the object area in the imaging was effectively detected and the image noise was removed.

Published: 2015.   Source: Bio-Medical Materials and Engineering 26 (2015) S1223–S1230

Ordering information

Send request about PhotoSonus M